Multiparametric MRI for Characterization of Hepatocellular Carcinoma

Summary

This prospective observational study investigates using multiparametric magnetic resonance imaging (MRI) to improve the characterization and management of therapy for hepatocellular carcinoma (HCC). The goal is to evaluate whether advanced MRI parameters can support noninvasive diagnostic assessments and personalized treatment plans for patients with HCC. The study is being conducted at a single university center in Germany and includes adult patients with confirmed or suspected HCC. Participants will undergo standardized multiparametric MRI examinations, and the imaging data will be correlated with clinical, pathological, and therapeutic outcomes. No study-specific interventions or medications will be administered.

Eligibility

Inclusion Criteria:

* Age ≥18 years
* Confirmed or suspected diagnosis of HCC
* Scheduled to receive TACE or SIRT as part of standard clinical care
* Eligibility for liver MRI
* Willing and able to provide written informed consent

Exclusion Criteria:

* Contraindications to MRI (e.g., pacemakers, ferromagnetic implants, severe claustrophobia)
* Known allergy or intolerance to gadolinium-based contrast agents
* Renal insufficiency with estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m²
* Pregnancy or breastfeeding
* Inability to provide informed consent

Conditions4

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