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Sarcopenia and Neuromuscular Block in Gastrointestinal Cancer Surgery

RECRUITINGSponsored by Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Actively Recruiting
SponsorDr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Started2025-06-01
Est. completion2025-09-01
Eligibility
Age18 Years – 75 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07003061

Summary

This prospective observational study aims to evaluate the effects of sarcopenia on intraoperative neuromuscular block (NMB) in patients undergoing gastrointestinal cancer surgery. Adult patients scheduled for elective gastrointestinal cancer surgery will be grouped as sarcopenic or non-sarcopenic based on preoperative abdominal CT scans. Neuromuscular block parameters, including onset time, depth, duration, and recovery, will be objectively measured using TOF (Train-of-Four) monitoring. The study seeks to determine whether sarcopenia influences sensitivity to muscle relaxants and to contribute to individualized anesthesia management and patient safety.

Eligibility

Age: 18 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* Patients aged between 18 and 75 years
* Patients diagnosed with gastrointestinal system (GIS) cancer and scheduled for elective surgery
* Patients who have undergone preoperative abdominal computed tomography (CT) imaging
* Patients classified as American Society of Anesthesiologists (ASA) physical status I-III

Exclusion Criteria:

* Patients with a history of neuromuscular diseases
* Patients receiving chronic steroid or immunosuppressive therapy
* Patients with electrolyte imbalance
* Patients using medications that affect neuromuscular transmission
* Patients with severe organ failure in the preoperative period (e.g., liver or renal failure)
* Patients who refuse to participate in the study
* Patients requiring emergency surgery
* Patients using muscle relaxants in the preoperative period

Conditions4

CancerGastrointestinal CancerNeuromuscular BlockadeSarcopenia

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