Mood Effects of Serotonin Agonists: Depression

Summary

This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.

Eligibility

Inclusion Criteria:

* English Fluency
* high school education or higher
* BMI between 19-30 kg/m2

Exclusion Criteria:

* individuals with a medical condition contraindicating study participation as determined by the study physician (e.g., liver disease, abnormal EKG, liver or cardiovascular disease)
* high blood pressure (\>140/90)
* current suicidal ideation or suicide attempt in past 12 months
* past year severe substance use disorder
* personal or first-degree relative with history of psychosis
* currently taking any psychiatric medication (for conventional antidepressants must be off for ≥ 2 weeks)
* active panic disorder
* severe obsessive-compulsive disorder
* severe post-traumatic stress disorder
* women who are pregnant or planning to become pregnant

Conditions3

Locations1 site

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