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PSMA PET for the Staging and Management of Hepatocellular Carcinoma

RECRUITINGSponsored by VA Office of Research and Development
Actively Recruiting
SponsorVA Office of Research and Development
Started2024-09-19
Est. completion2027-12-30
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations2 sites
View on ClinicalTrials.gov →

NCT07019844

Summary

This prospective, single-center study evaluates the clinical utility of F18-Piflufolastat (PSMA) PET/CT when added to conventional cross-sectional imaging for patients with suspected or confirmed hepatocellular carcinoma (HCC). The study aims to determine whether PSMA PET/CT improves diagnostic accuracy for indeterminate liver lesions (LI-RADS 3 and 4), enhances staging precision in treatment-naïve patients, and provides more accurate assessment of treatment response in patients undergoing locoregional therapy (LRT). The goal is to assess how PSMA PET/CT may impact clinical decision-making, staging, and management of HCC across multiple stages of disease.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Adult patients age \>18 years from the VA medical system
* Treatment-naïve patients with HCC with BCLC B or C disease

Exclusion Criteria:

* Patients with renal dysfunction or contrast allergy that precludes contrast enhanced cross sectional imaging
* Patients with presence of active primary malignancy other than HCC and non-melanoma skin cancer in the past 3 years

Conditions4

CancerHepatocellular Carcinoma (HCC)Liver CancerLiver Disease

Locations2 sites

California

1 site
VA Greater Los Angeles Healthcare System, West Los Angeles, CA
West Los Angeles, California, 90073-1003
Anthony Bejjani, MD(31-0) -3711anthony.bejjani@va.gov

Florida

1 site
Miami VA Healthcare System, Miami, FL
Miami, Florida, 33125
Binu V John, MD MPH(305) 575-7000binu.john@va.gov

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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