Methacholine Challenge Test in School Children With/Without Asthma RISKA

Summary

The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed. At the study visit, a methacholine challenge test measuring airway hyperresponsiveness and an exhaled nitric oxide measurement are performed. The effect of medication intensification in asthma patients is further assessed through a telephone interview 1-2 months after the medication adjustment.

Eligibility

Inclusion Criteria: Healthy Controls

* • Aged 7-15 years, both sexes

  * No diagnosis of asthma in childhood
  * No inhaled asthma medication during the previous 2 years
  * No wheezing or shortness of breath during the previous 2 years
  * Written informed consent from the participant and guardian

Inclusion Criteria: Children with Asthma

* Aged 7-15 years, both sexes
* Physician-diagnosed asthma (ICD-10 codes J45.0/J45.1/J45.9)
* Inhaled corticosteroid treatment for at least 6 months
* Either:

  * Well-controlled asthma (c-ACT/ACT score ≥20) and no clinical need to intensify medication, or
  * Poorly controlled asthma with physician-confirmed need for intensified asthma medication

Exclusion Criteria:

* • Premature birth before 32 gestational weeks

  * Other chronic cardiopulmonary or neurological conditions affecting airways (excluding asthma)
  * Severe underlying illness such as malignancy
  * Beta-blocker medication
  * Active immunological disease

Conditions4

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