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Natural History of Advanced Chronic Liver Diseases

RECRUITINGSponsored by Chinese University of Hong Kong
Actively Recruiting
SponsorChinese University of Hong Kong
Started2024-09-25
Est. completion2035-12
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07042308

Summary

This is a retrospective-prospective registry cohort study. Patients with advanced chronic liver disease (ACLD) will be prospectively invited to this study. The study follow-up duration will be 10 years. The primary outcome is incident hepatic events and liver-related mortality. Participants will undergo annual transient elastography examination.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Aged 18 or above
* Known ACLD, defined by:

  * LSM \> 10kPa or
  * Clinical cirrhosis, suggested by 1. ultrasonography of the hepatobiliary system shows features of cirrhosis (e.g. shrunken and nodular liver) and portal hypertension (e.g. dilated portal vein, portal-systemic collaterals or varices, splenomegaly, ascites). 2. Oesophagogastroduodenoscopy (OGD) shows presence of oesophageal varices (OV) and/or gastric varices (GV) and/or portal hypertensive gastropathy.

Exclusion Criteria:

* Current or past history of hepatocellular carcinoma (HCC)
* History of liver transplantation
* Asplenism or history of splenectomy
* Serious medical illness with limited life expectancy of less than 6 months
* Pregnancy
* Unable to obtain or refusal of informed consent from patient

Conditions3

Advanced Chronic Liver DiseaseCirrhosisLiver Disease

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