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The Characteristics and Treatment Mechanism of Vascular Grafts in Elderly Patients With CAOD Through Single-cell Transcriptome Analysis

RECRUITINGSponsored by Yonsei University
Actively Recruiting
SponsorYonsei University
Started2022-04-12
Est. completion2027-04-11
Eligibility
Age19 Years – 100 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07053254

Summary

This study aims to establish a cardiovascular biobank using vascular grafts obtained from participants with coronary artery occlusive disease (CAOD). Through genomic and transcriptomic analyses, the study seeks to characterize the biological features of the vascular grafts and identify potential therapeutic targets and mechanisms related to vascular remodeling and stiffness.

Eligibility

Age: 19 Years – 100 YearsHealthy volunteers accepted
Inclusion Criteria:

* Adults aged 19 years or older, Patients scheduled to undergo coronary artery bypass grafting (CABG), Patients who voluntarily provide written informed consent for study participation, Patients who are able and willing to comply with study procedures during the study period

Exclusion Criteria:

* Pediatric or adolescent patients under 18 years of age, Patients requiring concomitant surgical correction for valvular heart disease, Patients undergoing reoperative (redo) cardiac surgery, Patients who decline to provide informed consent prior to surgery

Conditions2

Coronary Artery Occlusive Disease (CAOD)Heart Disease

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