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The ACHILLS Trial; Application of Cerament in Heel Infection for Lower Limb Salvage

RECRUITINGN/ASponsored by Royal College of Surgeons, Ireland
Actively Recruiting
PhaseN/A
SponsorRoyal College of Surgeons, Ireland
Started2026-01-01
Est. completion2029-07
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07057817

Summary

The ACHILLS Trial is a multicentre randomised controlled feasibility study comparing partial calcanectomy with and without the use of an antibiotic-impregnated bone graft substitute (Cerament G) for treating calcaneal osteomyelitis, specifically on wound healing rates, re-infection, and overall efficacy in a sample of 30 patients over a one-year period.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* 18 and over
* Undergoing partial calcanectomy
* Patients with Type1 or Type 2 Diabetes
* Patients will be stratified by Pulse status and eGFR

Exclusion Criteria:

* Patients unfit for surgery
* Patients unable to provide informed consent
* Patients with overwhelming sepsis that require major amputation
* Patients with hypersensitivity to aminoglycosides
* Pre-existing calcium metabolism disorder
* Severe renal impairment
* Patients in whom major limb amputation is deemed inevitable by the treating physician

Conditions3

CalcanectomyDiabetesOsteomyelitis

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