Effect of Rehabilitation at Moderate Altitude on Airway Resistance Measured With Forced Oscillation Technique in COPD-patients

Summary

Airway resistance will be measured using the forced oscillation technique (FOT). The parameters Rrs, Xrs, and ∆Xrs will be compared before and after a pulmonary rehabilitation cycle at moderate altitude. Additionally, the differences between low and moderate altitude will also be examined.

Eligibility

Inclusion Criteria:

* Aged ≥18 years
* Stable clinical condition for \>3 weeks (e.g., no exacerbations)
* Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and/or a level below 90% during the 6MWT
* Informed consent documented by signature

Exclusion Criteria:

* Severe daytime resting hypoxemia (SpO₂ \<88%)
* Long-term oxygen therapy
* Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities
* Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle)
* Women who are pregnant or breastfeeding
* Enrolment in another clinical trial involving active treatment

Conditions1

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