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Weaning Approaches for Vasopressin in Sepsis

RECRUITINGPhase 3Sponsored by Hospital Nossa Senhora da Conceicao
Actively Recruiting
PhasePhase 3
SponsorHospital Nossa Senhora da Conceicao
Started2025-10-01
Est. completion2027-12-31
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07067866

Summary

In this study, we aim to evaluate the incidence of hypotension during vasopressin weaning by comparing two methods - titrated reduction versus abrupt withdrawal - through the conduct of a randomized clinical trial.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age over 18 years
* Admitted to the Intensive Care Unit
* Patients with vasopressor dependent sepsis
* Receiving combined norepinephrine and vasopressin therapy

Exclusion Criteria:

* Withdrawal/reduction of vasopressin related to a plan of treatment limitation or palliative care
* Withdrawal/reduction of vasopressin associated with the initiation of adrenaline or any other vasopressor

Conditions2

DiabetesSeptic Shock

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