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Observational Study on APL-like aCute Myeloid Leukemia: disTInct Phenotype and Early VAscular complicaTions

RECRUITINGSponsored by Gruppo Italiano Malattie EMatologiche dell'Adulto
Actively Recruiting
SponsorGruppo Italiano Malattie EMatologiche dell'Adulto
Started2026-07
Est. completion2027-12
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07080970

Summary

This is a multicenter observational study with a retrospective and a prospective cohort investigating clinically and biologically the APL-like subset as a potential predictor of coagulopathy and susceptibility to early vascular events.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Patients with de novo AML, untreated, newly diagnosed, according to WHO/ICC 2022 criteria from January 2015 onwards.
* Presence of NPM1 mutation.
* Availability of immunophenotypic characterization at diagnosis
* Age \>= 18 years
* Signed written informed consent according to ICH/EU/GCP and national local laws (if applicable)

Exclusion Criteria:

* No specific exclusion criteria are provided once eligibility criteria are met.

Conditions3

Acute Myeloid LeukemiaCancerNPM1 Mutation

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