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Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Parkinson's Disease Patients With Hypovitaminosis D

RECRUITINGN/ASponsored by Bangladesh Medical University
Actively Recruiting
PhaseN/A
SponsorBangladesh Medical University
Started2025-07
Est. completion2025-10
Eligibility
Age51 Years – 70 Years
SexMALE
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07084597

Summary

The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male Parkinson's disease patients with hypovitaminosis D Main questions it aims to answer are: 1. Does vitamin D improves heart rate variability(HRV) in male Parkinson's disease patients ? 2. Does vitamin D improves cardiac autonomic nerve function in male Parkinson's disease patients ? It is a self control trial. Vitamin D3 deficient Parkinson's disease participants will a. undergo through baseline HRV test b. Then they will take vitamin D3 capsule 50000 IU once in a week for 8 consecutive weeks c. Then after intervention with vitamin D supplementation post interventional HRV will be done. Researcher will compare pre intervention(pre test) and post intervention(post test) value of HRV

Eligibility

Age: 51 Years – 70 YearsSex: MALEHealthy volunteers accepted
IInclusion criteria:

* Male patients with of Parkinson's disease diagnosed by neurologist with unilateral or bilateral involvement and mild to moderate disability according to Hoehn and Yahr (H-Y) scale (I-III)
* Age: 51-70 years
* BMI: 18.5-24.9 kg/m2
* Vitamin D3 deficient or insufficient
* On Levodopa medication

Exclusion criteria:

1. Patients with a history of drug abuse including alcoholism.
2. Patients on following drugs will be excluded-

   * Antioxidant vitamin supplements
   * Lipid lowering medications
   * Antihypertensive drug
   * Anti-arrhythmic drug
   * Sedatives
3. All patients with the history of or clinical manifestation of currently suffering from following diseases \& condition will be excluded

   * Severe Cardiovascular disorders
   * Severe neurological disorders
   * Severe Respiratory disorders
   * Severe Renal insufficiency (S. Creatinine \> 1.5 mg/dl, Acute or chronic kidney disease)
   * Severe Endocrine disease
   * Severe Arthritis
   * Severe Liver diseases
   * Severe Neoplastic disease
   * Severe Psychiatric disorder
   * Current use of iron, zinc, calcium, magnesium and multivitamin supplementation
   * Already performing yoga or breathing exercise
   * Hypercalcemia

Conditions3

Heart DiseaseParkinson DiseaseParkinson's Disease

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