Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Epileptic Patients With Hypovitaminosis D

Summary

The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male epileptic patients with hypovitaminosis D that weather vitamin D improves heart rate variability or not. The main questions it aims to answer are: 1. Does vitamin D improves cardiac autonomic tone in male epileptic patients? 2. Does vitamin D improves heart rate variability in male epileptic patients? It is a self control trial. Participants will: 1. undergo through baseline HRV testing 2. start to take vitamin D3 50000 IU once in a week for 8 weeks b) visit the university after 8 weeks for post interventional HRV testing . Researcher will compare the pre test and post test value of HRV testing.

Eligibility

Inclusion Criteria:

* • Diagnosed male patients with Epilepsy by neurologist from the OPD of Department of Neurology by taking proper history of at least two unprovoked (or reflex) seizures occuring \> 24 hours apart, from patients and eye witnesses.

  * Having hypovitaminosis D (serum vitamin D3 level \<30 ng/ml)
  * Age: 20-40 years.

    * Sex: Male
    * BMI : 18.5-24.9 kg/m2
    * Taking antiepileptic drug for 6 months to 2 years ( Enzyme inducer AEDs, e.g. Carbamazepine, Phenytoin, Phenobarbital)
    * Without medication that affect central nervous system other than antiepileptic drugs (AEDs).

Exclusion Criteria:

* • Epileptic patients taking Sodium valproate, oxcarbazepine, Topiramate, Lamotrigine, Levetiracetam.

  * Patient having absence seizure
  * Alcoholic
  * Smoker
  * Patients taking following drugs will be excluded-

    * Anti-diabetic drugs
    * Antioxidant vitamin supplements
    * Antihypertensive drug
    * Anti-arrhythmic drug
    * Lipid lowering medications
    * Sedatives
  * Patients having known hypersensitivity to vitamin D3
  * All patients with the history of or currently suffering from following diseases \& condition will be excluded-

    * Cardiovascular disorders (Myocardial infarction, coronary heart disease, cardiac arrhythmia, CCF)
    * Other neurological disorders (Migraine, stroke)
    * Respiratory disorders (Bronchial asthma, COPD)
    * Renal insufficiency (S. Creatinine \> 1.5 mg/dl, Acute or chronic kidney disease)
    * Endocrine disease (Diabetes mellitus, Thyroid disorders- hypothyroidism, hyperthyroidism)
    * Arthritis (rheumatoid arthritis)
    * Liver diseases
    * Neoplastic disease
    * Psychiatric disorder (schizophrenia, bipolar disorder)
    * Current use of iron, zinc, calcium, magnesium and multivitamin supplementation
    * Already performing yoga or breathing exercise
    * Patients with hypercalcemia

Conditions2

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