|

Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

RECRUITINGN/ASponsored by The Cleveland Clinic
Actively Recruiting
PhaseN/A
SponsorThe Cleveland Clinic
Started2025-08-25
Est. completion2026-01-31
Eligibility
Age18 Years – 85 Years
Healthy vol.Accepted
Locations2 sites
View on ClinicalTrials.gov →

NCT07087587

Summary

A pilot N-of-1 randomized controlled trial evaluating the effectiveness of a personalized CPAP intervention in reducing atrial fibrillation (AF) burden and improving AF-related quality of life in patients with moderate to severe obstructive sleep apnea (OSA).

Eligibility

Age: 18 Years – 85 YearsHealthy volunteers accepted
Inclusion Criteria:

1. Informed consent
2. Age 18-85 years
3. High burden paroxysmal AF (≥1%)
4. Moderate-severe OSA (AHI ≥ 15)
5. Implanted device with atrial diagnostics
6. Enrolled in remote monitoring

Exclusion Criteria:

1. AF ablation \<6 months
2. Valvular abnormalities
3. Excessive daytime sleepiness in safety-critical jobs
4. Plans for ablation during study
5. Non-CPAP OSA treatment
6. Recent device implantation (\<6 months)
7. Central sleep apnea

Conditions4

AfibCPAPHeart DiseaseSleep Apnea Syndrome, Obstructive

Locations2 sites

Ohio

1 site
Cleveland Clinic
Cleveland, Ohio, 44195

Washington

1 site
University of Washington
Seattle, Washington, 98195
Reena Mehra, MD216-272-7405mehrar@uw.edu

Browse More Trials

Heart Disease trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.