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Effect of Vitamin D3 on Brain Waves in Male Parkinson's Patients With Low Vitamin D: A qEEG Study

RECRUITINGN/ASponsored by Bangladesh Medical University
Actively Recruiting
PhaseN/A
SponsorBangladesh Medical University
Started2025-07-15
Est. completion2025-11
Eligibility
Age51 Years – 70 Years
SexMALE
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07096336

Summary

This is an experimental study (Interventional self-controlled trial, pretest-posttest design). The goal of this clinical trial is to evaluate the effect of vitamin D3 supplementation on quantitative EEG in male Parkinson's disease patients with hypovitaminosis D. The main question it aims to answer is: Vitamin D3 supplementation has effect on brain waves in male Parkinson's disease patients with hypovitaminosis D. Researcher will compare the effect of vitamin D3 supplementation on brain waves in male Parkinson's disease patients with hypovitaminosis D with their pre intervention ( baseline ) condition on brain waves to assess whether there will be any improvement of brain electrical activity by quantitative electroencephalogram (QEEG). Participants will : Take vitamin D3 orally for 8 weeks (50,000 IU/week) Visit the medical university after 8 weeks for evaluation of serum 25(OH)D level and QEEG Must bring the empty strips of vitamin D supplement with them during their visit.

Eligibility

Age: 51 Years – 70 YearsSex: MALEHealthy volunteers accepted
Inclusion Criteria:

* Male Patients with PD up to stage 3 according to Hoehn and Yahr (H-Y) scale
* Age: 51years to70 years
* BMI: 18.5-24.9 kg/m2
* Hypovitaminosis D (Serum 25(OH)D level \<30 ng/ml)
* Patients on Levodopa therapy

Exclusion Criteria:

* Already taking vitamin D3 supplements
* Current use of medication/substances known to affect neuronal excitability or EEG patterns, such as - sedatives, antidepressant, antipsychotics, alcohol.
* Patients who are currently suffering from following diseases

  * Neurological disorders (Migraine, epilepsy)
  * Cardiovascular disorders (Myocardial infarction, hypertension, cardiac arrhythmia, heart failure)
  * Respiratory disorders (Bronchial asthma, COPD)
  * Psychiatric illness (e.g., schizophrenia, major depression, bipolar disorder, severe dementia)
* With biochemical evidence of-

  * Hypercalcemia
  * Renal insufficiency
  * Liver diseases
  * Endocrine disorders (uncontrolled diabetes mellitus, Hypothyroidism, Hyperthyroidism)
* Active smoker

Conditions2

PARKINSON DISEASE (Disorder)Parkinson's Disease

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