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Determinants of the Response to BTK Degraders (BTKd) in Chronic Lymphocytic Leukemia

RECRUITINGSponsored by Nantes University Hospital
Actively Recruiting
SponsorNantes University Hospital
Started2025-10-09
Est. completion2039-09-15
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07099443

Summary

The aim of the REBELLE cohort - bio-collection is to collect samples from patients with Chronic Lymphocytic Leukemia candidates or those exposed to BTK degraders to evaluate the mechanisms of resistance to these new molecules. To do this, an additional blood or bone marrow sample to those planned in the context of patient care or a residual lymph node biopsy sample will be collected after signing consent.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Patient with CLL candidates ou exposed to BTKd
* Patient who has provided informed consent to participate in the study.
* Patient covered by a social security health insurance plan

Exclusion Criteria:

* Minor patients.
* Adults under guardianship.
* Protected persons.

Conditions4

BTK DegradersCancerChronic Lymphocytic LeukemiaRefractory Chronic Lymphocytic Leukemia

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