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Strength Training Response of Muscle in GLP-1 Users

RECRUITINGN/ASponsored by Virginia Polytechnic Institute and State University
Actively Recruiting
PhaseN/A
SponsorVirginia Polytechnic Institute and State University
Started2025-10-08
Est. completion2026-12
Eligibility
Age50 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07104539

Summary

GLP-1 medication is being prescribed for weight loss. However, GLP-1 medication may adversely affect muscle mass and muscle function. Moreover, any loss of muscle mass or muscle function with GLP-1 treatment may impair balance and increase fall risk. This is a particular concern among older adults already susceptible to the common muscle strength and muscle function loss with age, yet there is little evidence among this population. This study will address a gap in knowledge regarding the effects of GLP-1 treatment on muscle mass, muscle function, and balance/fall risk among adults age 50 and older.

Eligibility

Age: 50 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age, 50y+
* Be taking GLP-1 medicine (Weygovy or Zepbound) for 1 month or less
* Weight \<300 lb
* Pass a health and exercise readiness screening

Exclusion Criteria:

* Age \<50
* Weight \>300 lb
* Osteoporosis
* Active metabolic, neoplastic, or cardiovascular disease
* Unable or unwilling to provide consent

Conditions2

Muscle MassWeight Loss

Locations1 site

Virginia Tech
Blacksburg, Virginia, 24061

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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