|

Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial

RECRUITINGN/ASponsored by Medical University Innsbruck
Actively Recruiting
PhaseN/A
SponsorMedical University Innsbruck
Started2025-08-14
Est. completion2029-12-31
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07107568

Summary

The goal of this clinical trial is to determine whether a non-invasive coronary assessment strategy using photon-counting detector computed tomography (PCD-CT) is non-inferior to invasive coronary angiography (ICA) for evaluating coronary artery disease (CAD) prior to transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age ≥ 18 years
* Severe aortic valve stenosis and indication for intervention according to current European Society of Cardiology (ESC) guidelines
* TAVR candidate
* Written informed consent

Exclusion Criteria:

* Cardiogenic shock at presentation (e.g., emergency indication for TAVR)
* Severe renal impairment with an estimated glomerular filtration rate of \<30 mL/min/1.73 m²
* Life expectancy \<1 year due to other severe non-cardiac disease (e.g., malignancy)
* Pregnancy

Conditions4

Aortic Valve Stenosis and InsufficiencyCoronary Artery Disease (CAD)Heart DiseaseTranscatheter Aortic Valve Replacement (TAVR)

Browse More Trials

Heart Disease trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.