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Visugromab in Cachexia International Trial

RECRUITINGPhase 2/3Sponsored by CatalYm GmbH
Actively Recruiting
PhasePhase 2/3
SponsorCatalYm GmbH
Started2026-04-16
Est. completion2029-12
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations6 sites

Summary

A study of how well and safely a new drug called visugromab works in people with certain kinds of cancer (including lung and bowel cancer) and unintended weight loss known as cachexia. The main questions it aims to answer are: * Does visugromab help participants put weight back on and have a better appetite? * Does visugromab help participants move more and better? * What medical problems do participants have when taking visugromab? Researchers will compare visugromab to a placebo (a look-alike substance that contains no drug). Participants will visit the hospital or clinic once every 4 weeks to receive visugromab or placebo via a drip into a vein and to undergo checkups and tests.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Weight loss
* Advanced cancer

Exclusion Criteria:

* Participation in another interventional clinical trial, receipt of any investigational therapy or use of any investigational device within 4 weeks prior to screening and between screening and the first dose of investigational product

Conditions3

CancerCancer-associated CachexiaWeight Loss

Interventions1

Locations6 sites

Clermont Oncology Center
Clermont, Florida, 34711
Mid Florida Hematology and Oncology Centers
Orange City, Florida, 32763
Cleveland Clinic Avon Hospital
Avon, Ohio, 44011
Cleveland Clinic (Main Campus)
Cleveland, Ohio, 44195
Cleveland Clinic Fairview Hospital
Fairview, Ohio, 44111

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