Pressure-Volume Loop Assessment in Valvular Heart Disease

Summary

The VHD PV loop study intends to assess invasive right ventricular to pulmonary artery (RV-PA) coupling in patients with valvular heart disease (VHD). Invasive RV-PA coupling is measured by using conductance catheters, the gold standard assessment for ventricular physiology. Several non-invasive parameters have been reported as surrogates for this complex physiological entity, but none of them has been tested against the gold-standard in this population. Based on this, our main objective is to assess the correlation of imaging derived RV-PA coupling in comparison to the invasive measurement.

Eligibility

Inclusion Criteria:

* Adult patients (≥ 18 years old);
* Patients with severe structural heart disease (meeting at least one of the following three criteria):

  * Heart failure with moderate-to-severe or severe secondary mitral regurgitation
  * At least severe tricuspid regurgitation
  * Significant pulmonary valve stenosis and/or regurgitation

Exclusion Criteria:

* Patients under legal guardianship or protection (e.g., guardianship, trusteeship, or any other legal protection measure);
* Pregnant or breastfeeding women;
* Vulnerable individuals (e.g., persons deprived of liberty, adults under legal protection);
* Contraindication to right heart catheterization, including:

  * Known proximal venous occlusion of the superior or inferior vena cava territory
  * Presence of a mobile mass in the right heart chambers
  * Significant tricuspid stenosis

Conditions4

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