tDCS Intervention in Breast Cancer Survivors With and Without Obesity Reporting Cognitive Impairment

Summary

The goal of this intervention is to investigate whether transcranial Direct Current Stimulation (tDCS) can alleviate Cancer-Related Cognitive Impairment (CRCI) in breast cancer survivors, as measured by changes in brain structures and cognitive performance. To assess the efficacy of tDCS, the investigators will compare outcomes between participants receiving active stimulation and those receiving sham stimulation (a placebo condition where participants believe they are receiving stimulation, but are not). Participants will: * Undergo a baseline MRI session * Receive either active or sham tDCS for six weeks * Undergo a follow-up MRI session * Complete cognitive tests and respond to psychosocial questionnaires before, during, and after the tDCS intervention

Eligibility

Inclusion Criteria:

* Female
* Over 18 years old
* Diagnosed with primary adult-onset breast cancer within the last 5 years
* Completed all active cancer treatments at least 3 months prior to study participation
* Capable of fulfilling study requirements, including having internet access.
* Fluent in either Finnish or English
* Have normal or corrected vision and hearing
* Right-handed (based on the Edinburgh Handedness Inventory score; Oldfield, 1971)

Exclusion Criteria:

* Have received primary cancer treatment (chemotherapy, radiotherapy, immunotherapy, or surgery) within the last 3 months
* Have a history of childhood-onset cancer
* Present with acute eczema on the scalp
* Diagnosed with dementia, Alzheimer's disease, multiple sclerosis, or - Parkinson's disease
* Have experienced unconsciousness for more than five minutes due to a head/brain injury within the last 10 years
* Have a history of stroke or transient ischemic attack
* Suffer from claustrophobia
* Are pregnant or breastfeeding
* Have any of the following medical implants or devices: cardiac implantable electronic devices, metallic intraocular foreign bodies, neurostimulation systems, cochlear/ear implants, drug infusion pumps, catheters with metal components, metallic fragments (e.g., bullets), cerebral aneurysm clips, magnetic dental implants, tissue expanders, artificial limbs, non-removable piercings, or face tattoos.
* Weight exceeding 250 kg (the MRI table weight limit) or they are unable to fit within the 70 cm diameter bore of the MRI machine

Conditions4

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