A Study of AK130 in Combination With AK112 for the Treatment of Advanced Pancreatic Cancer

Summary

This is an open-label, multi-center phase II clinical study consisting of two parts: Part I: To evaluate the safety and efficacy of AK130 combined with AK112 in advanced pancreatic cancer. Part II: To evaluate the safety and efficacy of AK112, either as monotherapy or in combination with AK130, in advanced pancreatic cancer.

Eligibility

Inclusion Criteria:

* Be able and willing to provide written informed consent.
* Have a life expectancy of at least 3 months.
* Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Subjects with histologically or cytologically confirmed advanced/metastatic pancreatic ductal adenocarcinoma (PDAC), who have progressed on ≤2 prior lines of systemic therapy.
* According to RECIST v1.1, there is at least one measurable lesion.
* Has adequate organ function.
* All subjects of reproductive potential must agree to use an effective method of contraception, as determined by the Investigator, during and for 90 days after the last dose of study treatment.
* Able to to comply with all requirements of study participation (including all study procedures).

Exclusion Criteria:

* Except for PDAC, the subjects had other malignant tumors within the 5 years prior to enrollment.
* There is central nervous system (CNS) metastasis, spinal cord compression, or meningeal metastasis.
* There are pleural effusion, pericardial effusion, or ascites with clinical symptoms or requiring repeated drainage.
* Prior systemic therapy with either TGF-β inhibitors or anti-angiogenic agents.
* There is a history of non infectious pneumonia that requires systemic glucocorticoid treatment.
* History of severe bleeding tendency or coagulation dysfunction.
* Previous history of myocarditis, cardiomyopathy, and malignant arrhythmia.
* Pregnant or lactating female subject.

Conditions2

Interventions2

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• A Phase II Study of AK112 (PD1/VEGF Bispecific) in Combination with Chemotherapy in Patients with NSCLC — Sichuan University
• A Prospective, Multicenter, Phase Ib/II Trial of Ivonescimab (AK112) Combined With Albumin-Paclitaxel and Cisplatin as Neoadjuvant Therapy for ESCC — Tang-Du Hospital
• A Study of AK112 as Consolidation Treatment for Patients With Limited Stage Small-cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy — Akeso
• A Study of AK112 in Patients With Advanced Hepatocellular Carcinoma (HCC) — Akeso
• A Study of AK130 in Combination With AK112 for the Treatment of Advanced Biliary Tract Cancer — Akeso
• A Study on Ivonescimab Plus Chemotherapy as Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer — Tianjin Medical University Cancer Institute and Hospital
• AK112 and Chemotherapy in First-line Metastatic Colorectal Cancer — Akeso

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