|

EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)

RECRUITINGSponsored by Liaquat University of Medical & Health Sciences
Actively Recruiting
SponsorLiaquat University of Medical & Health Sciences
Started2021-06-01
Est. completion2025-12-30
Eligibility
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07122128

Summary

Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing. Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.

Eligibility

Healthy volunteers accepted
Inclusion Criteria:

* healthy volunteers
* patients with oral submucous fibrosis
* patients with biopsy proven oral cancer

Exclusion Criteria:

* patients with oral infection

Conditions2

CancerThe Study Focuses on the Saliva as Potential Source of Early Detection of Oral Cancer

Browse More Trials

Cancer trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.