Optimizing Liver MRI Using Breath-Holding With and Without Oxygen

Summary

The goal of this interventional study (clinical trial) is to learn if different breath-holding techniques, with and without extra oxygen, can improve the quality of abdominal Magnetic Resonance Imaging (MRI) images in healthy adults, ages 18-75. The main questions it aims to answer are: * Does breath-holding at end-expiration improve image quality in abdominal MRI scans? * Does adding oxygen while breath-holding further reduce motion artifacts in abdominal MRI scans? Researchers will compare breath-holding with and without oxygen to see if using oxygen improves image quality during MRI scans. Participants will: * Be pre-screened for MRI safety and trained on breath-hold procedures * Have one non-contrast abdominal MRI scan at the University of California San Francisco (UCSF) China Basin Imaging Center * Use two different breath-holding techniques during the scan, with and without oxygen * Complete one study visit lasting about 45 minutes to 1 hour

Eligibility

Inclusion Criteria:

* Subject must be within 18-75 years of age;
* Subject must be able to hear and understand instructions without assistive devices;
* Subject must provide written informed consent;
* Subject has the necessary mental capacity to understand instructions, and is able to comply with protocol requirements;
* Subject is able to remain still for duration of imaging procedure (approximately 30-45 minutes)

Exclusion Criteria:

* Subjects with a weight greater than 499 lbs;
* Subjects that have metallic/conductive or electrically/magnetically active implants without Magnetic Resonance (MR) Safe or Magnetic Resonance (MR) Conditional labeling, with the exception of dental devices/fillings, surgical clips, and surgical staples determined to be safe for MRI scanning by a physician investigator;
* Subjects that have implants with MR Unsafe labeling;
* Subjects that have implants labeled as MR Conditional by the manufacturer for which the allowable conditions are not expected to be achieved by the MR environment or scan protocol;
* Subjects who have a contraindication to MRI per the screening policy of the participating site;
* Subjects with any respiratory or cardiovascular condition that could compromise safe breath holding;
* Subjects who are female and pregnant

Conditions3

Locations1 site

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