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Anastomotic Leakage After Colorectal Surgery.

RECRUITINGSponsored by Minia University
Actively Recruiting
SponsorMinia University
Started2025-08-25
Est. completion2026-08-25
Eligibility
Age18 Years – 80 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07144683

Summary

Anastomotic leakage (AL) is a severe complication after colorectal surgery, with incidence rates of 2-30%. This prospective, single-center observational cohort study aims to identify and quantify independent risk factors for AL, determine its incidence and impact on outcomes, and develop a predictive model. Approximately 430 patients undergoing colorectal resection with anastomosis will be enrolled from August 2025 to August 2026. Risk factors will be assessed preoperatively, intraoperatively, and postoperatively. AL will be defined and graded per the International Study Group of Rectal Cancer (ISGRC) criteria.

Eligibility

Age: 18 Years – 80 YearsHealthy volunteers accepted
Inclusion Criteria:

* Aged ≥18 years
* Undergoing elective or emergency colorectal resection with primary anastomosis (e.g., ileocolic, colocolic, colorectal, coloanal)
* Providing written informed consent

Exclusion Criteria:

* Colorectal resection without anastomosis (e.g., end stoma)
* Inflammatory bowel disease (Crohn's, ulcerative colitis)
* History of previous colorectal surgery involving anastomosis
* Pregnancy
* Unable to provide informed consent or comply with follow-up

Conditions4

Anastomotic LeakCancerColorectal CancerDiverticulitis

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