|

Transcranial Magnetic Stimulation and Psychotherapy for Treating Obsessive-Compulsive Disorder

RECRUITINGN/ASponsored by Adam Frank
Actively Recruiting
PhaseN/A
SponsorAdam Frank
Started2025-11-10
Est. completion2028-06
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07146438

Summary

This study will test how people with OCD respond to a type of noninvasive brain stimulation, repetitive Transcranial Magnetic Stimulation (rTMS), when it is combined with psychotherapy. Participants will either engage in Exposure and Response Prevention (ERP) Therapy or supportive therapy (ST) while receiving rTMS. Biobehavioral data from wearable devices and smartphones will be collected to better predict treatment responses. Participants will also undergo repeat resting state functional Magnetic Resonance Imaging (rsfMRI) in order to assess neural predictors and mechanisms of treatment response.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Diagnosis of Obsessive-Compulsive Disorder (OCD) as determined by Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria.
* Live in Southern California and be willing to attend in-person to receive repetitive Transcranial Magnetic Stimulation (rTMS) 5 times per week for 6 weeks.
* Have completed a prior course of Exposure and Response Prevention (ERP) therapy (at least ten sessions)
* Currently take or have previously tried Serotonin Reuptake Inhibitor (SRI) medication for OCD
* Willing to maintain psychotropic medication levels throughout the 16 weeks of the study

Exclusion Criteria:

* Primary psychiatric diagnosis other than OCD
* Active substance use disorder
* Active suicidality
* Active psychosis
* History of seizures
* Severe neurological impairment
* Pregnant or planning to become pregnant
* Received a prior rTMS course

Conditions2

AnxietyObsessive-compulsive Disorder

Locations1 site

University of Southern California Health Sciences Campus
Los Angeles, California, 90033
Frank OCD Lab323-230-0162frankocdlab@usc.edu

Browse More Trials

Anxiety trials

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

This site does not provide medical advice. Always consult your doctor before considering enrollment in a clinical trial. Learn more on our About page.