Clinical Efficacy and Mechanism of tDCS for Dysphagia in PD

Summary

This study aims to verify transcranial direct current stimulation(tDCS) efficacy for Parkinson's disease (PD)-related dysphagia and its mechanism. Subjects are randomly split into two groups: control (sham tDCS + conventional dysphagia treatment) and experimental (real tDCS + conventional treatment). Assessments will be conducted at baseline, after the completion of intervention, and at the 3-month follow-up. Swallowing function will be evaluated via gold-standard videofluoroscopic swallowing study (VFSS) and scales. Resting-state functional magnetic resonance imaging (rs-fMRI) or functional near-infrared spectroscopy (fNIRS) will be measures for tracking changes in abnormal brain regions/networks. Correlations between swallowing recovery and brain function changes, plus group imaging differences, will reveal tDCS's neurophysiological mechanism.

Eligibility

Inclusion Criteria:

* Meet the Chinese Diagnostic Criteria for Parkinson's Disease (2016) or MDS Diagnostic Criteria for Multiple System Atrophy or Progressive Supranuclear Palsy;
* VFSS examination indicates dysphagia;
* Mini-Mental State Examination (MMSE) score \>23;
* Willing to cooperate with the study and sign the informed consent form;

Exclusion Criteria:

* Comorbid with other diseases that cause dysphagia;
* Comorbid with pneumonia, or severe cardiac/renal insufficiency;
* Having metal implants in the body
* With cognitive impairment or inability to cooperate.

Conditions3

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