Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease

Summary

This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits. Using Positron Emission Tomography (PET) scans with amyloid tracers - a conventional tool for non-invasively imaging amyloid deposits in Alzheimer's disease - the research will extend this imaging methodology to the heart. The study will conduct additional PET/MRI scans of the heart in patients undergoing amyloid tracer PET scans for Alzheimer's evaluations. Each participant will also undergo an echocardiogram and a clinical examination of dementia. This could potentially enhance diagnostic practices in both cardiac amyloidosis and Alzheimer's disease.

Eligibility

Inclusion Criteria:

* Patients undergoing cerebral amyloid PET examination for clinical indication to clarify Alzheimer's disease
* No contraindications to undergo an MRI examination
* No contraindications to undergo an Amyloid PET scan

Exclusion Criteria:

* Patients with vascular dementia and confirmed other causes of dementia (e.g. stroke, vitamin deficiency, thyroid insufficiency, toxic causes such as alcohol)
* Patients with pronounced cardiac preconditions
* Pregnant and breastfeeding women

Conditions5

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