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Postural Mobilization Compared to Noradrenaline Only in Off-Pump CABG Surgery

RECRUITINGN/ASponsored by Infirmerie Protestante de Lyon
Actively Recruiting
PhaseN/A
SponsorInfirmerie Protestante de Lyon
Started2025-10-06
Est. completion2027-07
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07163858

Summary

This interventional prospective randomized study is designed to compare hemodynamic management using postural mobilization (+/- noradrenaline) versus noradrenaline only in patients undergoing open-heart coronary artery bypass graft (CABG) surgery.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Adult patient
* patient requiring isolated coronary bypass surgery
* Elective procedure or medical emergency
* First cardiac surgery
* Patient with an EF ≥30%
* Mandatory affiliation to a social security system
* Signed informed consent form
* Suspension of renin-angiotensin system inhibitors and angiontensn-neprilysin receptor blockers and sartans the day before surgical procedure

Exclusion Criteria:

* Contraindication to an inotropic substance (only NA will be used)
* Contraindication to passive leg raising
* Patient in a life-threatening emergency
* History of cardiac surgery
* Bilateral iliac or common femoral artery occlusion
* EF \< 30%
* Pregnancy and breastfeeding
* Renal failure (GFR \< 40 ml/min/1.73 m²)
* Patient with bilateral thigh amputation
* Class III obesity BMI \> 40 kg/m²

Conditions9

Coronary Artery BypassCoronary Artery Disease (CAD)Coronary Artery Disease With Need for Bypass SurgeryHeart DiseaseHemodynamic ManagementHemodynamic OptimizationNoradrenalineOff Pump Coronary Artery Bypass GraftOff Pump Coronary Artery Bypass Surgery

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