Dexmedetomidine vs Propofol in High-Risk ERCP Patients

Summary

ERCP requires deep sedation due to pain and discomfort, but propofol-commonly used with opioids-often causes respiratory and cardiovascular complications, especially in elderly or high-risk patients. Dexmedetomidine offers sedation without respiratory depression but may lower blood pressure and heart rate. Current monitoring often relies only on SpO₂, while capnography and the Integrated Pulmonary Index (IPI) provide earlier detection of respiratory events but are underused in ERCP studies. This study compares dexmedetomidine and propofol in high-risk ERCP patients, focusing on respiratory and hemodynamic effects, propofol consumption, recovery, and discharge times. The hypothesis is that dexmedetomidine will cause fewer adverse respiratory and hemodynamic effects.

Eligibility

Inclusion Criteria:

* patients over 18 years of age
* ASA physical status III-IV
* scheduled for ERCP in the Gastroenterology Endoscopy Unit of our hospital

Exclusion Criteria:

* pregnant women;
* patients with neuropsychiatric disease,
* substance abuse, or known allergy to the sedatives used;
* patients with baseline heart rate ≤50 bpm;
* those who did not provide consent.

Conditions6

Browse More Trials