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Quantitative and Qualitative Monocytes Analysis and Their Impact on CART Cells Reponse in Multiple Myeloma

RECRUITINGSponsored by Centre Hospitalier Universitaire, Amiens
Actively Recruiting
SponsorCentre Hospitalier Universitaire, Amiens
Started2025-07-16
Est. completion2028-09
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07180992

Summary

Tumoral micro-environment in malignant haematological diseases, notably in multiple myeloma, is active on plasma cells survival and proliferation. Monocytosis and monocytes typing are described in multiple myeloma response as factors on proliferation and cell death evasion. CART cells have improved multiple myeloma care in last 5 years, nethertheless, early relapse occur and we must identify predictor factors of better response. The aim of this study is to analyze basic level and phenotyping of monocytes before and after CART cells infusion and study their impact on multiple myeloma response

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Patients over 18 years old
* Treated for a multiple myeloma
* CART cells treatment proposed
* Affiliated to social security system
* Agreed to participate to the study

Conditions4

CART CellsCancerMonocytesMultiple Myeloma

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