A Study Looking at a New Nerve Surgery to Help Men Regain Erections After Prostate Cancer Surgery

Summary

A single arm prospective pilot trial evaluating the 1-year erectile recovery outcomes and the safety of patients undergoing a somatic to autonomic nerve grafting procedure for restoration of erectile function in patients who have lost erectile function following radical prostatectomy for prostate cancer. During this study a total of 100 patients who have persistent erectile dysfunction for more than 18 months post prostatectomy will undergo a post radical prostatectomy nerve restoration procedure (PRP-NR).

Eligibility

Inclusion Criteria:

* Patients with persistent post prostatectomy erectile dysfunction as defined below:

  1. Severe ED (IIEF score 5-7) and more than 12 months from prostatectomy OR
  2. Moderate ED (IIEF score 8-11) and more than 18 months from prostatectomy
* Patients must have had good pre-prostatectomy erectile function with a baseline IIEF score of ≥17 on self-reported assessment of historic function.

Exclusion Criteria:

* Patients aged \< 18 years at diagnosis
* Legally incapable patients
* Patients \>5 years from prostatectomy.
* Bilateral open inguinal hernia repair
* Patients with pre-existing significant neurologic disease
* Diabetes with evidence of peripheral nerve involvement and end organ dysfunction
* Coronary artery disease with unstable angina
* Mood disorder (anxiety/depression) with change in medical therapy within last 3 months
* Pre-existing penile base surgery which would prevent grafting technique including suprapubic liposuction, suspensory ligament release
* Pre-existing penile prosthesis
* Current use of androgen deprivation therapy
* Use of medications for chronic nerve pain (gabapentin, amitriptyline, nortriptyline, pregablin)
* Previous untreated penile trauma
* Patients deemed medically unfit for surgery

Conditions3

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