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Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning

RECRUITINGSponsored by Centre Hospitalier de Saint-Denis
Actively Recruiting
SponsorCentre Hospitalier de Saint-Denis
Started2025-04-11
Est. completion2026-04-11
Eligibility
Age18 Years+
View on ClinicalTrials.gov →

NCT07193069

Summary

This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both metformin and dapagliflozin, another diabetes drug. The goal is to find clinical or laboratory signs that could help doctors quickly recognize a dapagliflozin overdose in this context, which could improve treatment and patient outcomes.

Eligibility

Age: 18 Years+
Inclusion Criteria:

* Adults aged 18 years or older
* Admission to an intensive care unit (ICU) due to acute drug poisoning
* Documented exposure to either:
* Metformin alone
* Metformin in combination with dapagliflozin

Exclusion Criteria:

* Patients under 18 years of age
* No exposure to metformin
* Exposure to dapagliflozin without metformin

Conditions7

DapagliflozinDiabetesDiabetic KetoacidosisDrug OverdoseIntensive Care UnitsLactic AcidosisMetformin

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