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Identification of Brain Injury Using Portable MRI

RECRUITINGSponsored by Yale University
Actively Recruiting
SponsorYale University
Started2025-12-02
Est. completion2027-04
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07197918

Summary

The goal of this study is to look for brain injury in patients who had a cardiac arrest, using portable brain imaging. The portable nature of this test will also allow for serial imaging so the investigators can understand how brain injury changes over days. The results of this study may allow for bedside imaging to be available at centers without specialized imaging centers and may identify markers of brain injury that help to select the patients most likely to benefit for clinical trials.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Unresponsive immediately after ROSC from IHCA or OHCA
* Age ≥ 18 years of age
* Conventional MRI is clinically indicated
* Treatment with temperature control

Exclusion Criteria:

* MRI contraindication according to the American Heart Association guidelines
* Inability to tolerate supine positioning for 30 minutes
* Diffuse loss of grey-white differentiation and sulcal effacement on head computed tomography within 6 hours of ROSC

Conditions3

Cardiac Arrest (CA)Heart DiseaseHypoxic-Ischemic Brain Injury

Locations1 site

Yale New Haven Hospital
New Haven, Connecticut, 05620

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