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A ELN-Multicenter Study on Phenotypic Evolution and Clinical Outcomes

RECRUITINGSponsored by FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Actively Recruiting
SponsorFROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Started2025-12-01
Est. completion2026-04-30
Eligibility
Age18 Years – 100 Years
Healthy vol.Accepted
Locations1 site

Summary

International multicenter retrospective observational study consisting of two parts: a nested case-control study (part A) and a comparative retrospective cohort study (part B).

Eligibility

Age: 18 Years – 100 YearsHealthy volunteers accepted
Inclusion Criteria:

\- ET patients (diagnosed according to "International consensus classification of myeloid neoplasms and acute leukemias - 2022" criteria) who are JAK2V617F positive and have progressed to PV (diagnosed according to "International consensus classification of myeloid neoplasms and acute leukemias - 2022" criteria) by 31/12/2020. The date of PV diagnosis will be defined as the index date and this group of patients will be defined as ET-to-PV cases.

Exclusion Criteria:

* None.

Conditions3

CancerPolycythemia VeraThrombocythemia

Locations1 site

Mayo Clinic
Rochester, Minnesota, 55905-0001
Ayalew Tefferi, MD

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