Inter- and Intraindividual Variability of the Acute Glucose Response to Exercise in Healthy Adults and People Living With Type 1 Diabetes: A Cross-over Replicate Trial

Summary

The goal of this clinical trial is to investigate if blood glucose responses are similar between and within individuals in response to standardized exercise in adults with and without Type 1 diabetes. The main questions it aims to answer are: What is the reproducibility of acute glycaemic responses to exercise within and between subjects in adults living with Type 1 Diabetes and in healthy adults? What is the agreement between glucose levels obtained by continuous glucose monitor (CGM) and blood glucose monitor? Participants will cycle on a cycle ergometer or rest after consuming a standardized breakfast, while glucose levels are monitored by CGM and capillary blood sampling.

Eligibility

Inclusion Criteria:

(Healthy and T1D phases):

* age between 18 and 60 years old;
* being healthy individuals;
* engagement in physical activity at least once a week; (T1D phase):
* diagnosis of T1D for \>18 months;
* hypoglycaemia self awareness.

Exclusion Criteria:

(Healthy and T1D phases)

* presence of cardiovascular disease or contraindications to exercise;
* infectious or inflammatory conditions;
* chronic renal or liver disease;
* pregnancy;
* gestational diabetes;
* diagnosed eating disorders;
* any physical or mental condition preventing participation; (Healthy phase)
* diabetes mellitus (type 1 or type 2); (T1D phase)
* inability to self-manage diabetes.

Conditions5

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