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Disrupted Sleep and Concurrent Ectopy or Atrial Fibrillation

RECRUITINGN/ASponsored by University of California, San Francisco
Actively Recruiting
PhaseN/A
SponsorUniversity of California, San Francisco
Started2025-12-15
Est. completion2027-06-01
Eligibility
Age21 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07220525

Summary

Whereas the available evidence mostly supports chronic sleep disruption as a risk factor for incident AF, less is known about the near-term risk of a discrete atrial fibrillation (AF) episode following a night of disrupted or poor-quality sleep. This prospective, randomized, case-crossover study aims to examine the acute effects of sleep disruption on clinically relevant cardiac ectopy pertinent to AF.

Eligibility

Age: 21 Years+Healthy volunteers accepted
Inclusion Criteria:

* Are age 21 years or older
* Have a HGNS device implanted for obstructive sleep apnea and followed up at UCSF Health
* Are willing to abstain from using the upper airway stimulation device for no more than two consecutive days as instructed over the 14-day trial period
* Able and willing to provide written informed consent

Exclusion Criteria:

* Currently pregnant or trying to get pregnant
* Are currently taking class 1 or 3 anti-arrhythmic medications
* Have a history of permanent AF or expected to have continuous AF throughout the study period
* Have congenital heart disease
* Ventricular pacing \>40%
* Are unable to read or sign to provide informed consent

Conditions5

Atrial Fibrillation (AF)Heart DiseaseObstructive Sleep ApneaPremature Atrial ContractionPremature Ventricular Contraction (PVC)

Locations1 site

UCSF Medical Center at Parnassus
San Francisco, California, 94143
Gregory Marcus, MD, MAS415-476-5706greg.marcus@ucsf.edu

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