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The Impact of Renal Transplant on Coronary Microvascular Function Among Patients With Advanced Chronic Kidney Disease

RECRUITINGSponsored by Brigham and Women's Hospital
Actively Recruiting
SponsorBrigham and Women's Hospital
Started2023-03-10
Est. completion2030-07
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07222683

Summary

People with chronic kidney disease (CKD) often experience faster aging of the heart and blood vessels, which raises the risk of heart problems beyond traditional factors like high blood pressure or cholesterol. One early sign is reduced blood flow in the tiny vessels that supply the heart, measured by a positron emission tomography (PET) scan using a marker called myocardial flow reserve (MFR). In CKD, ongoing inflammation and abnormal blood vessel growth can damage these small vessels, leading to heart stiffness and weaker heart function. A kidney transplant offers a unique chance to study how better kidney function and reduced inflammation affect heart health. The observational RESTORE study ("Impact of Renal Transplant on Coronary Microvascular Function in Patients with Advanced CKD") will measure heart blood flow and function before and after transplant. The study will test whether: 1. Inflammation and abnormal vessel growth are linked to poor heart blood flow and heart function in CKD. 2. Kidney transplant improves heart blood flow and function. 3. Lower inflammation after transplant leads to better heart health. By understanding how kidney disease and inflammation affect the heart-and how transplant may reverse these effects-this research could help guide future treatments to better protect heart health in patients with CKD.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Renal transplant candidate on the waitlist
* Age greater or equal to 45 years, or if 18-44 years of age on dialysis for 5 years or more

Exclusion Criteria:

* Left ventricular ejection fraction (LVEF) \< 40%
* History of coronary artery bypass grafting (CABG)
* History of heart transplant
* Patients who undergo revascularization as a result of pre-transplant cardiac PET

Conditions5

Chronic Kidney DiseaseCoronary Microvascular Dysfunction (CMD)Heart DiseaseInflammationKidney Transplant

Locations1 site

Brigham and Women's Hospital
Boston, Massachusetts, 02115
Daniel M Huck, MD, MPH8573074000dhuck@bwh.harvard.edu

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