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Liquid Biopsy Using Exosomal miRNA Enables Risk Stratification of Potential Metastasis in Patients With Intrahepatic Cholangiocarcinoma.

NOT_RECRUITINGSponsored by City of Hope Medical Center
No longer actively recruiting
SponsorCity of Hope Medical Center
Started2024-06-21
Est. completion2026-06-18
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07224737

Summary

Occult metastasis at the time of surgery is a major driver of poor outcomes in intrahepatic cholangiocarcinoma (ICC), yet reliable preoperative biomarkers to identify such patients are lacking. The EXOMIC study aims to develop and validate a circulating exosomal microRNA (exo-miRNA)-based liquid biopsy assay to detect occult metastasis preoperatively in patients with resectable ICC.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Histologically confirmed ICC (clinical stage I-III).
* Undergoing curative-intent hepatectomy.
* Availability of preoperative pasma or serum sample (≥200 µL).
* Standard staging imaging completed per institutional protocol.
* Written informed consent.

Exclusion Criteria:

* Extrahepatic cholangiocarcinoma or gallbladder cancer.
* Synchronous non-ICC malignancy.
* Inadequate clinical follow-up.
* Inability to consent.

Conditions5

CancerIntrahepatic Cholangiocarcinoma (ICC)Liver CancerLiver DiseaseLung Cancer

Locations1 site

City of Hope Medical Center
Duarte, California, 91016
Ajay Goel, PhD626-218-3452ajgoel@coh.org

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