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An Exosomal miRNA-based Liquid Biopsy for ICC Detection

NOT_RECRUITINGSponsored by City of Hope Medical Center
No longer actively recruiting
SponsorCity of Hope Medical Center
Started2024-06-21
Est. completion2026-06-18
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07225452

Summary

Intrahepatic cholangiocarcinoma (ICC) is a malignant liver tumor with poor prognosis and limited curative treatment options. Early and accurate detection remains an unmet clinical need. The LUMIC study aims to develop a non-invasive liquid biopsy platform based on both exosomal microRNAs (exo-miRNAs) to detect intrahepatic cholangiocarcinoma with high sensitivity and specificity.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Age ≥ 18 years
* Histologically confirmed intrahepatic cholangiocarcinoma
* Availability of pre-treatment plasma sample
* Informed consent provided

Exclusion Criteria:

* Extrahepatic cholangiocarcinoma
* History of other malignancy within 5 years
* Active infection, autoimmune disease, or pregnancy
* Inadequate clinical data or poor sample quality

Conditions5

CancerIntrahepatic Cholangiocarcinoma (ICC)Liver CancerLiver DiseaseLung Cancer

Locations1 site

City of Hope Medical Center
Duarte, California, 91016
Ajay Goel, PhD626-218-3452ajgoel@coh.org

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