Antenatal Myo-inositol Supplementation in Pre-existing Diabetes

Summary

This feasibility pilot study aims to gather data that can guide the design of a larger, more comprehensive trial to establish the effects of myo-inositol supplementation on supporting healthy outcomes in pregnancies complicated by Type 2 Diabetes Mellitus (T2DM). It seeks to assess myo-inositol's potential to support fetal and neonatal health, and optimise maternity outcomes as a complementary approach and adjuvant to existing diabetes mellitus therapies, as well as investigate the underlying biological mechanisms.

Eligibility

Inclusion Criteria

* Pregnant women aged 21 years to 45 years old at the time of recruitment
* Ongoing, viable, singleton intrauterine pregnancy
* Between 12+0 days-16+6 days weeks' gestation at recruitment
* T2DM diagnosed by a documented 75g Oral Glucose Tolerance Test (OGTT) showing a fasting glucose of \>7 mmol/L or 2h glucose \>11.1 mmol/L, or an HbA1C \>6.5%, either prior to pregnancy or during the first 16 weeks of the index pregnancy
* Intend to receive antenatal care and give birth at NUH
* Willing to provide written, informed consent
* Able to swallow capsules and comply with trial procedures

Exclusion Criteria

* Known or suspected fetal aneuploidy or genetic/structural anomaly
* Severe allergy to food items requiring carriage of an Epipen at all times

Conditions2

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