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A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006)

RECRUITINGPhase 1Sponsored by Merck Sharp & Dohme LLC
Actively Recruiting
PhasePhase 1
SponsorMerck Sharp & Dohme LLC
Started2025-12-22
Est. completion2026-08-28
Eligibility
Age18 Years – 75 Years
Healthy vol.Accepted
Locations4 sites
View on ClinicalTrials.gov →

NCT07242469

Summary

The purpose of this study is to learn about the safety and if people tolerate a study medicine called MK-1403. The study will also measure what happens to MK-1403 in the body of a person with type 2 diabetes (T2D) over time (pharmacokinetic or PK study), and how it affects the amount of high-sensitivity C-reactive protein (hsCRP) in a person's blood.

Eligibility

Age: 18 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* Has a confirmed diagnosis of Type 2 diabetes mellitus (T2DM)
* Has body mass index (BMI) between 18 and 40 kg/m\^2, inclusive

Exclusion Criteria:

* Has Type 1 diabetes mellitus or secondary types of diabetes
* Has a history of congestive heart failure (New York Heart Association \[NYHA\] Class 3 or 4)
* Has history of myocardial infarction, uncontrolled arrhythmias, cardiac revascularization, angina, unstable peripheral arterial disease and/or stroke
* Has history of cancer (malignancy)
* Has positive test(s) for hepatitis B surface antigen (HBsAg), hepatitis C antibodies, or human immunodeficiency virus (HIV)
* Has a history of gastrointestinal (GI) disease which might affect food and drug absorption, or has had gastric bypass or similar surgery

Conditions2

DiabetesDiabetes Mellitus, Type 2

Locations4 sites

California

1 site
ProSciento Inc. ( Site 0001)
Chula Vista, California, 91911
Study Coordinator619-427-1300

Florida

2 sites
QPS-MRA, LLC ( Site 0004)
Miami, Florida, 33143
Study Coordinator305-722-0970
Advanced Pharma CR, LLC ( Site 0003)
Miami, Florida, 33147
Study Coordinator305-220-2727

Missouri

1 site
Bio-Kinetic Clinical Applications, LLC dba QPS-MO ( Site 0005)
Springfield, Missouri, 65802
Study Coordinator417-831-2048

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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