Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

Summary

Participants in this research study have cancer that has spread to their brain, called brain metastases. One treatment for this type of cancer is called whole brain radiotherapy that stays away from a specific neurocognitive substructure, called the hippocampus, combined with medication to preserve cognitive function. This study compares that approach to another approach of whole brain radiotherapy that stays away from additional structures that are thought to have a role in cognitive function. Researchers want to see if there is a difference in the preservation of cognitive function between these two approaches.

Eligibility

Inclusion Criteria:

* Participants must have histologically, cytologically, or radiographically confirmed diagnosis of solid tumor with brain metastases
* Age \>18 years
* Performance status: Karnofsky Performance Status (KPS) ≥ 70
* Estimated life expectancy of at least 3 months
* Participant must be considered a candidate for WBRT by the treating physician
* Participant must be a primary English speaker and have the ability to understand and the willingness to sign an English written informed consent document
* Participant has at least 10 brain metastases or is otherwise suitable for WBRT

Exclusion Criteria:

* Prior whole brain radiation
* Participant has Multiple Sclerosis, Alzheimer's, dementia, or mental disability
* Pregnant or breastfeeding women are excluded from this study.
* Participant is not able to receive an MRI
* Participant has metastasis within avoidance neurocognitive substructures (hippocampus, amygdala, fornix, corpus callosum, pituitary, amygdala)

Conditions2

Interventions1

Locations1 site

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