Stress and Anxiety Effects on Valuation

Summary

The purpose of this study is to understand how stress, anxiety, and negative affect change learning and decision-making processes. The primary objective is to assess two forms of decision-making-reward adaptation and emotion prediction errors-differ as a function of stress and anxiety. The secondary objectives are to assess how individual differences measured in our studies relate to these decision variables.

Eligibility

Inclusion Criteria:

Aims 1-3: To be eligible for participation in this study, an individual must meet all of the following criteria:

* 18-65 years of age
* Able to speak, read, and write fluently in English
* Be willing and able to follow study procedures and provide informed consent.

Aim 4: To be eligible for participation in this study, an individual must meet all of the following criteria:

* 18-65 years of age
* Diagnosis of GAD
* Able to speak, read, and write fluently in English
* Be willing and able to follow study procedures and provide informed consent.

Exclusion Criteria:

Aims 1-3: Individuals will be excluded from participation if any of the following criteria are met:

* History of or medication for neurologic or psychiatric disease
* High-blood pressure or heart condition
* Diabetes, food allergies, metabolic disorders or history of eating disorder
* Use of corticosteroids or beta-blockers
* Pregnancy

Aim 4: Individuals will be excluded from participation if any of the following criteria are met:

* High-blood pressure or heart condition
* Diabetes, food allergies, metabolic disorders or history of eating disorder
* Use of corticosteroids or beta-blockers
* Lifetime history of bipolar disorder or any psychotic disorder; substance use disorder in past 3 months; eating disorder in past 6 months; current major depressive disorder (past is allowed)
* Active suicidal ideation with plan and intent (indicated by score \>=4 on the Columbia Suicide Severity Scale)
* Not on stable dose of psychiatric medication for at least 4 weeks prior to study participation
* Pregnancy

Conditions2

Locations1 site

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