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A Cell-free tsRNA Signature for Early Detection of Hepatocellular Carcinoma

RECRUITINGSponsored by City of Hope Medical Center
Actively Recruiting
SponsorCity of Hope Medical Center
Started2025-01-15
Est. completion2026-06-18
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07265271

Summary

Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and early detection is critical for improving patient outcomes. Despite this, reliable non-invasive biomarkers for early-stage HCC are limited. This study seeks to develop a cell-free tsRNA (cf-tsRNA)-based liquid biopsy assay for accurate detection of early-stage HCC.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* A histologically confirmed diagnosis of hepatocellular carcinoma.
* Received standard diagnostic and staging procedures as per local guidelines
* Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment

Exclusion Criteria:

• Lack of or inability to provide informed consent

Conditions4

CancerHepatocellular Carcinoma (HCC)Liver CancerLiver Disease

Locations1 site

City of Hope Medical Center
Duarte, California, 91016
Ajay Goel, PhD626-218-3452ajgoel@coh.org

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