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Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition

RECRUITINGN/ASponsored by Pennington Biomedical Research Center
Actively Recruiting
PhaseN/A
SponsorPennington Biomedical Research Center
Started2025-12
Est. completion2027-05
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07265323

Summary

The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention. The main questions it aims to answer are: Does the intervention improve insulin sensitivity (how the body uses glucose)? Does the intervention improve cognition, measured by the Montreal Cognitive Assessment (MoCA) and the Revised Memory and Behavior Problems Checklist (RMBPC)? What changes occur in brain glucose uptake (FDG-PET)? Participants will: Receive the intervention once a week for 6 months, with each session lasting up to 2 hours Complete cognitive assessments. Adverse events will be assessed throughout the study.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Mini Mental State Examination (MMSE) score \< 25

Exclusion Criteria:

* On daily medication for the specific treatment of anxiety including benzodiazepines.
* An infant, child, or teenager
* A pregnant woman
* A prisoner
* Having any condition that impedes testing of the study hypothesis or are otherwise deemed to be unsuitable (determined by the investigative team).

Conditions3

Alzheimer Blood BiomarkersAlzheimer's DiseaseInsulin Sensitivity

Locations1 site

Pennington Biomedical Research Center
Baton Rouge, Louisiana, 70806
Tim Gilbert, Dr2257632584Tim.Gilbert@pbrc.edu

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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