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ADAPT Forward - Master Protocol of a Platform Study to Evaluate the Safety and Efficacy of Multiple Regimens in Participants With Myasthenia Gravis

RECRUITINGSponsored by argenx
Actively Recruiting
Sponsorargenx
Started2025-12-19
Est. completion2028-03-07
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations5 sites
View on ClinicalTrials.gov →

NCT07294170

Summary

ADAPT Forward is a platform study with the aim to look at how safe different drugs are and how well they work for people with myasthenia gravis. The goal is to find the best therapeutic approach to reduce patients' side effects and improve their quality of life.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Is at least 18 years of age and the local legal age of consent for clinical studies
* Has been diagnosed with MG with consistent clinical features per the investigator's clinical judgment
* If receiving MG therapy, including nonsteroidal immunosuppressive drugs (NSIDs), corticosteroids, or acetylcholinesterase (AChE) inhibitors either in combination or alone, the participant should receive a stable dosage before master protocol screening

Exclusion Criteria:

* Known autoimmune disease or any medical condition other than the indication under study that would interfere with an accurate assessment of clinical symptoms of MG or puts the participant at undue risk
* Is MGFA (Myasthenia Gravis Foundation of America) Class V

Conditions7

AChR-Ab Seropositive Generalized Myasthenia GravisCancerGeneralized Myasthenia GravisGeneralized Myasthenia Gravis (gMG)MGMyasthenia GravisgMG

Locations5 sites

California

1 site
Profound Research LLC - Carlsbad
Carlsbad, California, 92011
Gregory Sahagian, MD857-350-4834clinicaltrials@argenx.com

Florida

1 site
Visionary Investigators Network
Miami, Florida, 33133
Andrew Lerman, MD857-350-4834clinicaltrials@argenx.com

Maryland

1 site
Erlanger Health System
Columbia, Maryland, 21044
Joshua Alpers, MD857-350-4834clinicaltrials@argenx.com

New York

1 site
Dent Neurologic Institute - Amherst
Amherst, New York, 14226
Luisa Rojas Estupinan, MD857-350-4834clinicaltrials@argenx.com

Texas

1 site
National Neuromuscular Research Institute
Austin, Texas, 78759
Yessar Hussain, MD857-350-4834clinicaltrials@argenx.com

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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