Impact of Lifestyle Interventions on Cognitive Decline in Non-alcoholic Fatty Liver Disease

Summary

This study investigates whether a structured lifestyle program can help improve thinking skills and liver health in adults with Non-Alcoholic Fatty Liver Disease (NAFLD). We are enrolling 45 participants, aged 18-42, who will be randomly assigned to one of three groups for six months: one receiving general health advice, a second following a supervised Mediterranean diet plan, and a third combining the same diet with a regular walking program. The main goal is to see if these diet and exercise interventions can lead to better scores on memory and reasoning tests, reduce liver stiffness measured by a painless scan (FibroScan), and improve related blood markers of inflammation and hormone balance.

Eligibility

Inclusion Criteria:

* Age 18 to 42 years.
* Diagnosed with fatty liver (NAFLD) via imaging (e.g., ultrasound).
* Liver fibrosis assessed and staged via FibroScan and the FIB-4 index.
* Literate (to consent and complete cognitive assessments/questionnaires).

Exclusion Criteria:

* History of alcohol intake \>20g/day.
* Chronic viral hepatitis B or C.
* Major neuropsychiatric illnesses.
* Pregnancy or breastfeeding.
* Chronic illnesses including Diabetes Mellitus and thyroid dysfunction.

Conditions3

Browse More Trials