HELP Study - Towards High Throughput and Efficient Long-axial PET With Oral [18F]FDG

Summary

Typically, PET scans involve an IV injection of 18F-FDG that helps identify cancer. Patients are scanned 60 minutes after injecting 18F-FDG. This study aims to assess the feasibility of a different method of administration - oral ingestion (rather than IV) of 18F-FDG through delayed imaging to identify the optimal time for scanning after consuming the drug. The study will aim to recruit 15-24 individuals who will receive two PET scans - one using delayed oral 18F-FDG imaging and a second regular 18F-FDG. The analysis will focus on establishing a suitable protocol for this administration route while considering patient preference and image quality.

Eligibility

Inclusion Criteria:

* Age ≥19 years
* Participants who have received a standard of care \[18F\]FDG PET/CT and are willing to undergo a study specific oral \[18F\]FDG PET/CT within 2 weeks.

Exclusion Criteria:

Participant Inclusion Criteria

* Age ≥19 years
* Participants who have received a standard of care \[18F\]FDG PET/CT and are willing to undergo a study specific oral \[18F\]FDG PET/CT within 2 weeks.

Participant Exclusion Criteria

* Pregnant or breast-feeding
* Medically unstable (e.g., acute illness, unstable vital signs)
* Urinary incontinence/catheter.
* Immobile, frail or vulnerable patients who cannot leave the department and would require an uptake room in any case.
* Patients whose fasting blood sugar at the SOC PET was \>11.0 mmol/l
* Unable to swallow.
* Patients with nasogastric tubes, percutaneous gastrostomy or other non-anatomical routes for nutrition.
* Unable to lie flat for 1h (subset of participants - first 5 participants only).
* Claustrophobia requiring medication.
* Undergoing active treatment or assessment of an upper digestive tract tumor (stomach/esophagus)
* Unable to provide written consent
* Patients receiving biguanide anti-hyperglycemic agents (e.g. Metformin).
* Insulin dependent diabetics.

Conditions4

Browse More Trials