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Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)

RECRUITINGPhase 3Sponsored by University Of Nigeria Teaching Hospital
Actively Recruiting
PhasePhase 3
SponsorUniversity Of Nigeria Teaching Hospital
Started2025-07-23
Est. completion2027-03-31
Eligibility
Age20 Years – 59 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07297290

Summary

Obesity is a chronic disease of global public health concern, contributing to cardiovascular disease, type 2 diabetes and certain cancers. Currently approved anti-obesity drugs and surgery are expensive and not readily available in Nigeria. Metformin, approved for type 2 diabetes, has been shown to promote weight loss among obese patients in high income countries. However, metformin's effects have not yet been demonstrated in Black African populations, which may have different genetic and environmental predispositions to obesity and to the effect of metformin. This blinded, placebo-controlled, randomized trial is determining the effect of metformin on weight loss, cardiovascular disease risk and insulin resistance in Black Nigerians.

Eligibility

Age: 20 Years – 59 YearsHealthy volunteers accepted
Inclusion Criteria:

* • Obesity (defined as body mass index ≥ 30kg/m2),

  * Fasting plasma glucose (\<7.0mmol/L)
  * No medical treatment for weight control in the previous 12 months
  * No participation in a current clinical trial

Exclusion Criteria:

* • Obesity (defined as body mass index ≥ 30kg/m2),

  * Fasting plasma glucose (\<7.0mmol/L)
  * No medical treatment for weight control in the previous 12 months
  * No participation in a current clinical trial

Conditions4

Insulin ResistanceObesity (Body Mass Index &gt;30 kg/m2)Obesity and Cardiovascular RiskWeight Loss

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